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2017 1
2018 30
2019 1
2021 1
2024 0

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31 results

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Page 1
Uremic toxins are conditional danger- or homeostasis-associated molecular patterns.
Sun Y, Johnson C, Zhou J, Wang L, Li YF, Lu Y, Nanayakkara G, Fu H, Shao Y, Sanchez C, Yang WY, Wang X, Choi ET, Li R, Wang H, Yang XF. Sun Y, et al. Front Biosci (Landmark Ed). 2018 Jan 1;23(2):348-387. doi: 10.2741/4595. Front Biosci (Landmark Ed). 2018. PMID: 28930551 Free PMC article.
We made the following observations: 1) UTs represent only 1/80(th) of human serum small-molecule metabolome; 2) Some UTs are increased in CKD and CVD; 3) UTs either induce or suppress the expression of inflammatory molecules; 4) The expression of UT genes is signifi …
We made the following observations: 1) UTs represent only 1/80(th) of human serum small-molecule metabolome; 2) Some UTs are increase …
Alteration of RNA Splicing by Small-Molecule Inhibitors of the Interaction between NHP2L1 and U4.
Diouf B, Lin W, Goktug A, Grace CRR, Waddell MB, Bao J, Shao Y, Heath RJ, Zheng JJ, Shelat AA, Relling MV, Chen T, Evans WE. Diouf B, et al. SLAS Discov. 2018 Feb;23(2):164-173. doi: 10.1177/2472555217735035. Epub 2017 Oct 6. SLAS Discov. 2018. PMID: 28985478 Free PMC article.
Splicing is an important eukaryotic mechanism for expanding the transcriptome and proteome, influencing a number of biological processes. Understanding its regulation and identifying small molecules that modulate this process remain a challenge. We developed an assay based …
Splicing is an important eukaryotic mechanism for expanding the transcriptome and proteome, influencing a number of biological processes. Un …
A simplified charge projection scheme for long-range electrostatics in ab initio QM/MM calculations.
Pan X, Nam K, Epifanovsky E, Simmonett AC, Rosta E, Shao Y. Pan X, et al. J Chem Phys. 2021 Jan 14;154(2):024115. doi: 10.1063/5.0038120. J Chem Phys. 2021. PMID: 33445891 Free PMC article.
In a previous work [Pan et al., Molecules 23, 2500 (2018)], a charge projection scheme was reported, where outer molecular mechanical (MM) charges [>10 A from the quantum mechanical (QM) region] were projected onto the electrostatic potential (ESP) grid of …
In a previous work [Pan et al., Molecules 23, 2500 (2018)], a charge projection scheme was reported, where outer molecu …
Icariin Attenuates Interleukin-1β-Induced Inflammatory Response in Human Nucleus Pulposus Cells.
Hua W, Zhang Y, Wu X, Kang L, Tu J, Zhao K, Li S, Wang K, Song Y, Luo R, Shao Z, Yang S, Yang C. Hua W, et al. Curr Pharm Des. 2018 Feb 12;23(39):6071-6078. doi: 10.2174/1381612823666170615112158. Curr Pharm Des. 2018. PMID: 28619001
The expression of cyclooxygenase- 2 (COX-2), inducible nitric oxide synthase (iNOS), degrading enzymes, collagen II, aggrecan, mitogenactivated protein kinase (MAPK), and nuclear factor-kappa B (NF-kappaB)-related signaling molecules was assessed via western blotting. RESU …
The expression of cyclooxygenase- 2 (COX-2), inducible nitric oxide synthase (iNOS), degrading enzymes, collagen II, aggrecan, mitogenactiva …
Enantioselective γ-C(sp3)-H Activation of Alkyl Amines via Pd(II)/Pd(0) Catalysis.
Shao Q, Wu QF, He J, Yu JQ. Shao Q, et al. J Am Chem Soc. 2018 Apr 25;140(16):5322-5325. doi: 10.1021/jacs.8b01094. Epub 2018 Apr 11. J Am Chem Soc. 2018. PMID: 29629766 Free PMC article.
The chiral gamma-arylated alkylamine products are further transformed into chiral 2-substituted 1,2,3,4-tetra-hydroquinolines and spiro-pyrrolidines as important structural motifs in natural products and biologically active molecules....
The chiral gamma-arylated alkylamine products are further transformed into chiral 2-substituted 1,2,3,4-tetra-hydroquinolines and spiro-pyrr …
Alisol B 23-Acetate Inhibits IgE/Ag-Mediated Mast Cell Activation and Allergic Reaction.
Shao C, Fu B, Ji N, Pan S, Zhao X, Zhang Z, Qiu Y, Wang R, Jin M, Wen K, Kong D. Shao C, et al. Int J Mol Sci. 2018 Dec 18;19(12):4092. doi: 10.3390/ijms19124092. Int J Mol Sci. 2018. PMID: 30567287 Free PMC article.
Alisol B 23-acetate (AB23A), a natural triterpenoid, has been reported to exert hepatoprotective and antitumor activities. ...AB23A inhibited spleen tyrosine kinase (Syk) and the downstream signaling molecules including phospholipase Cgamma (PLCgamma), serine-threon …
Alisol B 23-acetate (AB23A), a natural triterpenoid, has been reported to exert hepatoprotective and antitumor activities. ...AB23A i …
Isolation and Purification of Two Isoflavones from Hericium erinaceum Mycelium by High-Speed Counter-Current Chromatography.
He J, Fan P, Feng S, Shao P, Sun P. He J, et al. Molecules. 2018 Mar 2;23(3):560. doi: 10.3390/molecules23030560. Molecules. 2018. PMID: 29498678 Free PMC article.
These two isoflavones were identified as genistein (4',5,7-trihydroxyisoflavone, C(15)H(10)O5) and daidzein (4',7-dihydroxyisoflavone, C(15)H(10)O4), using infrared spectroscopy (IR), electro-spary ionisation mass (ESI-MS), 1H-nuclear magnetic resonance (NMR) and (13)C-NMR spectr …
These two isoflavones were identified as genistein (4',5,7-trihydroxyisoflavone, C(15)H(10)O5) and daidzein (4',7-dihydroxyisoflavone, C(15) …
31 results